Avrupa Endokrin Cerrahisi Yeterlik Dershanesi – Bülten V

Merhabalar!
Bugün itibari ile e-dershane üye sayımız 50’ye ulaştı! UEMS-DES’in (Avrupa Tıp Uzmanları Birliği – Endokrin Cerrahisi Bölümü’nün) yeterlik sınavı için oluşturulan müfredata göre bu hafta 'Tiroiditler'i çalışacağız. Bu konu ile ilgili metnin orijinal İngilizce özetine, müfredatta yer alan ilgili bölümü tıklayarak da ulaşabilirsiniz. Bu başlıkla ilgili 1 dosya dershane üyelerine gönderilecektir. Üyeler dışında metinlere ulaşmak isteyenlerin bana e-posta ile ozer.makay@ege.edu.tr adresinden ulaşmaları yeterlidir.

Haftaya ‘Bülten VI’ ile görüşmek üzere! Kolay gelsin!
 

N Engl J Med. 2003 Jun 26;348(26):2646-55.
Thyroiditis.
Pearce EN, Farwell AP, Braverman LE.

World J Surg. 2008 May;32(5):688-92.
Hashimoto's thyroiditis.
Takami HE, Miyabe R, Kameyama K.

Goiters were often associated with iodine deficiency in European mountain areas, with some goiters being quite disfiguring. However, some goiters seem not to be related to iodine deficiency. One of the types of goiter that are unrelated to iodine deficiency is the disease described by Hakaru Hashimoto in 1912. Hashimoto described it as a special characteristic of a new type of lymphomatous thyroid tumor in Japan, and this entity was recognized as an autoimmune disease of the thyroid many years later. Hashimoto published his article in a German journal because that was the scientific language of the time, and he thought that writing in German would make the work more widely available around the world. Patients with Hashimoto's thyroiditis are usually asymptomatic, and some patients develop goiters with or without hypothyroidism. The goiters and hypothyroidism usually respond to treatment with thyroid hormone. The dose of thyroid hormone must be carefully titrated because there may be autonomous thyroid function resulting from thyroid-stimulating antibodies despite the hypothyroid state.

Am Fam Physician. 2006 May 15;73(10):1769-76.
Thyroiditis.
Bindra A, Braunstein GD.

Thyroiditis is an inflammation of the thyroid gland that may be painful and tender when caused by infection, radiation, or trauma, or painless when caused by autoimmune conditions, medications, or an idiopathic fibrotic process. The most common forms are Hashimoto's disease, subacute granulomatous thyroiditis, postpartum thyroiditis, subacute lymphocytic thyroiditis, and drug-induced thyroiditis (caused by amiodarone, interferon-alfa, interleukin-2, or lithium). Patients may have euthyroidism, hyperthyroidism, or hypothyroidism, or may evolve from one condition to another over time. Diagnosis is by clinical context and findings, including the presence or absence of pain, tenderness, and autoantibodies. In addition, the degree of radioactive iodine uptake by the gland is reduced in most patients with viral, radiation-induced, traumatic, autoimmune, or drug-induced inflammation of the thyroid. Treatment primarily is directed at symptomatic relief of thyroid pain and tenderness, if present, and restoration of euthyroidism.